Figure 8

p53 and p73 chimeric proteins with larger N- and C-terminal swaps. A, Schematic of the p53 and p73 chimeric proteins in which larger portions of the N- and C-terminus have been swapped. B, Saos-2 cells were co-transfected with 100 ng pG13-luc DNA and 50 or 100 ng DNA encoding the indicated protein from A. The fold change in pG13-luc activity is plotted compared to the activity of pG13-luc alone, whose value is considered 1.0. Results are the average from two experiments.