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Table 4 Predicted targets for differentially expressed miRNAs

From: Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model

miR-128a

VEGFC, CDK9, RAB20, ST14, THRAP1, TXNIP, TRAF1, LGALs3, PTPN6, SLC6A7, ADAMTS6, ITGA3, RAB27A RAB34, ILI9, Elf3S4, GDF15, CASP8, CDKN2A, DUSPSP, HTRA 2, HLA-G, CDH 4, PCDH3, IFITM1, TBC1D2, SERPINA3 CASP10, ZNF432, NEK2, MAP3K1IPI, CDH24

miR-128b

PLK2, PRKD1, ADORA2B, ZNF385, CASC3, PAIP2, ITGB4BP CRKL, CDH24, ING5, BAG2, EGFR, ST14, THRAP1 CORO1CE2F, E2F3, PDGFRA, INSR, CITED2, STX16

miR-139

JUN, GAS2, MYST3, PTPRF, TGIF, XPO4, GDF10, MAP2, PCDH10

miR-181a

TMED4, TGFB1, PRKCD, MLK1, MAP3K10, WTAP, TSGA10 FOS, TUPBP1, VCAM, DROSHA, IRS2, TNFAIP1, RASSF1, ILISR1, DDIT4, PLAG1, GPBP1, PRR6, APIP, CKSIB IL2, FGFR2, RAP1B

miR-370

RAB3IP, PTPRG, CCN5, VSP6, CCL21, CNTNAP1, LTBP1 MAP3K8, GFRA2, MMP16, CCNK, ETV6, FGF7, THRAP2 BRCA1, FOSB

miR-302c

RAB43, CELSR3, NOTCH1, MET, CALCR, NOTCH2, THRAP2, TPO52, DAAMI, PDGFRA, MAD1A

  1. Upregulated miRNAs in ret/PTC 1 cell lines = miR-128a, miR-128b, miR139
  2. Downregulated miRNAs in ret/PTC 1 cell lines = miR-181a, miR-370, miR-302c
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Molecular Cancer

ISSN: 1476-4598