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Table 1 Immunohistochemical Staining for Perlecan and Co-Localization with Ki-67.

From: Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

  

Perlecan Negative

Perlecan Positive

 

Histology

Tumor

170

203

 
 

Normal

211

31

p < 0.00005

 

Tumor

170

203

 
 

HGPIN

46

7

p < 0.00005

Clinical Stage

cT2

11

12

 
 

cT3/4

2

3

N.S.

Tumor Grade

Gleason 6

26

5

 
 

Gleason 7,8,9

38

23

p = 0.0335

Pathologic Stage

pT1-pT2

35

17

 
 

pT3

29

11

N.S.

Nodal Status

pN0

18

23

 
 

pN1

0

1

N.S.

Outcomes

PSA Recurrence

4

5

 
 

No PSA Recurrence

13

22

N.S.

Vital Status

Alive

26

36

 
 

Dead

2

5

N.S.

Perlecan Expression in Metastasis

Metastatic Site

 

Perlecan Negative

Perlecan Positive

P value vs. Prostate

Primary Tumor (Prostate)

 

3

24

 

Lymph Node

 

8

9

p = 0.0073

Soft Tissue

 

15

18

p = 0.0039

Liver

 

5

23

p = 0.4781

Lung

 

3

24

p = 1.000

Association of Ki-67 (PCNA) Staining with Perlecan Staining

Sample Staining

 

Number of Samples

Mean % of Ki-67 positivity

Two-tailed ANOVA

Perlecan positive

 

143

6.715278

p = 0.0478

Perlecan negative

 

214

5.028571

 
  1. * Tumor grade is presented as Gleason score. Pathologic staging uses the American Joint Commission on Cancer (AJCC) 2002 tumor staging criteria. HGPIN = high grade prostatic intraepithelial neoplasia.
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Molecular Cancer

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