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Figure 9 | Molecular Cancer

Figure 9

From: Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy

Figure 9

The anti-proliferative activity of AICAR is enhanced by the addition of the mTOR inhibitor rapamycin in ALL cells. CCRF-CEM, NALM6, REH, and SupB15 ALL cells were incubated for 24 h with either AICAR alone (0.25 mM for CCRF-CEM, NALM6, REH, and 1.0 mM for SupB15), 1 μg/ml rapamycin alone, or a combination of both drugs (Rapa + AICAR) and cell proliferation determined using the tetrazolium (MTS) reduction assays. The cell proliferation values are expressed as a percentage relative to those obtained with untreated control cells (mean ± SEM, n = 3). #, p < 0.005 for AICAR vs. Rapa + AICAR.

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Molecular Cancer

ISSN: 1476-4598