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Table 1 Effects of swainsonine on the sensitivity to 5-FU in the parental and resistant sublines.

From: Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines

 

Swainsonine (-)

Swainsonine (+)

 

IC-50 (μg/mL)

Ratio

IC-50 (μg/mL)

Ratio

L0 (colon 26)

0.110

1.00

0.110

1.00

L0-200

1.07

9.70

0.650

5.91

L0-500

3.87

35.1

1.45

13.2

L0-1000

4.86

44.2

3.01

27.4

  1. IC-50s were calculated from the cell viability data obtained by MTT assay (n = 6).
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Molecular Cancer

ISSN: 1476-4598