Figure 3
From: Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas
CD44 expression is dependent on Fra-1 and the pathways that control Fra-1 expression. (A) Western blot showing the effect of the PI3K and Src inhibitors in the CD44 expression of an SV40+ and SV40- cell line. (B) Western blots showing that CD44 expression in the SV40- MM line follows the pattern of its Fra-1 expression. The use of a dominant negative construct for Fra-1 (dnFra-1) decreases CD44 expression, but not further decreases are observed after PD98059 or LY294002 is added to the dnFra-1 stable cell line.