Gene expression profiles in primary pancreatic tumors and metastatic lesions of Ela-c-myc transgenic mice

Table 4 Downregulated genes in liver metastatic lesions. Relative fold change in liver metastatic lesions compared to primary pancreatic tumors (LM/PT) and in primary pancreatic tumors compared to normal pancreas (PT/NP)

Entrez Gene #	LM/PT	PT/NP	Gene Symbol	Gene description	Ref.*
Cell communication and Signal transduction
22329	0.5	23.5	Vcam1	Vascular cell adhesion molecule 1
58194	0.4	4.0	Sh3kbp1	SH3-domain kinase binding protein 1
15186	0.1	15.0	Hdc	Histidine decarboxylase
11438	0.2	4.9	Chrna4	Cholinergic receptor, nicotinic, alpha polypeptide 4
12524	0.6	4.6	Cd86	CD86 antigen
93761	0.2	4.2	Smarca1	SWI/SNF related, regulator of chromatin, subfamily a, member 1
Cell motility and migration
12767	0.7	4.7	Cxcr4	Chemokine (C-X-C motif) receptor 4	25
17381	2.8	7.6	Mmp12	Matrix metallopeptidase 12	16
11438	0.2	4.9	Chrna4	Cholinergic receptor, nicotinic, alpha polypeptide 4
Cell Adhesion
12505	0.6	5.3	Cd44	CD44 antigen	11
22329	0.5	23.5	Vcam1	Vascular cell adhesion molecule 1
Cell death and apoptosis
18616	0.2	11.2	Peg3	Paternally expressed 3
11801	0.6	31.1	Cd5l	CD5 antigen-like
58194	0.4	4.0	Sh3kbp1	SH3-domain kinase binding protein 1
Inflammatory and Immune response
20210	0.1	14.1	Saa3	Serum amyloid A 3
58194	0.4	4.0	Sh3kbp1	SH3-domain kinase binding protein 1
15186	0.1	15.0	Hdc	Histidine decarboxylase

Ref.* = References identifying genes previously shown to have deregulated expression in pancreatic cancer

ISSN: 1476-4598