Figure 3
From: Epigenetic changes within the promoter region of the HLA-G gene in ovarian tumors
Methylation analysis of the HLA-G promoter in tumor and normal ovarian samples. (A) Schematic map of 450 bp of the HLA-G promoter region (See Figure 2 legend for symbols). (B) Bisulfite genomic sequencing of 19 CpG dinucleotides of the region from -450 to the transcription start site is analyzed for 18 ovarian adenocarcinomas (red) and benign adenomas (green) and four normal ovaries (black). Five to eight clones were sequenced for each sample and each circle represents the average methylation for a single CpG dinucleotide (open circle = 100% unmethylated; filled circle = 100% methylated; %M = percentage of total methylation per sample).