Figure 2From: Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cellsMean HDACi IC50 values of mock treated or HDAC deprived HeLa cells. HDAC1 KD significantly increases the resistance to belinostat on average 1.9-fold (p < 0.01, n = 10), which is not observed for HDAC2 or -3 KD cells. For VPA, no significance was obtained for the 1.4-fold-changes seen in response to both HDAC1 and -3 KD (n = 5). For all figures, standard errors of the mean IC50 value for each condition are shown. The chemical structures for belinostat and VPA are shown over the graphs.Back to article page