Figure 5
From: Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
EF24 sensitizes the HSC 72OT+A cell line to MMC but not its FA-deficient counterpart, HSC 72OT. A) Effect of the combination of MMC and EF24 treatment on the viability of HSC 72OT and HSC 72OT+A cells. HSC 72OT (patient-derived FANCA-deficient cell line) and HSC 72OT+A (FANCA-complemented isogenic cell line) were treated with various concentrations of MMC only (solid lines) or MMC + 100 nM EF24 (dashed lines). Cell viability was measured after 3 days by MTS assay. B) Similar experiment was performed using EF24 only.