Figure 6
From: Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
EF24 but not curcumin or DRB is more toxic to ATM-deficient mouse kidney cells than wild-type cells. A) 309ATM KO and 334ATM WT cells were treated with various concentrations of EF24. Cell viability was measured after 3 days by MTS assay. Each point represents the mean of 3 repeats. Error bars represent standard deviation. B) Similar experiment was performed using curcumin. C) Similar experiment was performed using DRB, a caseine kinase II inhibitor that does not inhibit the FA pathway in Xenopus extracts.