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Table 1 Nearby gene mapping of validated ChIP-cloned sequences.

From: STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells

Chr

Start

End

% DNA-b.

Strand

Dir.

Gene Name

Loc.

1

212539607

212540208

40.79

+

U

SMYD2

I

    

-

U

PTPN14

E

1

184551050

184551638

46.99

+

U

PRG4

IDS

    

+

D

C1orf27

E

    

-

U

TPR

I

1

148762360

148762960

17.71

+

U

ECM1

E

    

+

D

ADAMTSL4

E

    

-

U

C1orf138

E

    

-

D

APH1A

E

1

85509312

85509912

18.52

+

U

WDR63

E

    

-

U

BCL10

I

    

-

D

C1orf52

E

1

172086277

172086887

3.81

+

U

DARS2

I

    

+

D

ZBTB37

E

    

-

U

SERPINC1

E

    

-

D

CENPL

E

1

210194877

210195427

35.81

+

D

DTL

E

    

-

U

INTS7

I

    

-

D

LPGAT1

E

2

38751513

38752103

47.52

+

U

GALM

I

    

+

D

GEMIN6

E

    

-

U

SFRS7

E

    

-

D

HNRPLL

E

3

140069314

140069963

5.83

+

U

FAIM

E

    

-

U

FOXL2

E

    

-

D

PIK3CB

E

4

77775984

77776232

18.02

+

U

SHRM

I

    

-

U

LOC345079

E

    

-

D

 

E

12

12538539

12539089

13.72

+

U

LOH12CR1

E

    

+

D

CREBL2

E

    

-

U

DUSP16

I

    

-

D

MANSC1

E

12

22082357

22083007

41.9

+

D

CMAS

E

    

-

U

ST8SIA1

E

    

-

D

ABCC9

E

12

88442012

88442661

26.03

-

U

WDR51B

I

    

-

D

DUSP6

E

13

102554697

102555277

9.23

+

U

ERCC5

E

    

-

D

SLC10A2

E

13

73026115

73026665

34.44

-

U

KLF12

E

14

68177078

68177617

35.78

+

U

RAD51L1

E

    

-

U

ZFP36L1

E

15

24494535

24495711

32.64

+

D

GABRA5

E

    

-

U

GABRB3

I

16

73675183

73675822

40.32

+

U

ZNRF1

I

    

+

D

ZFP1

E

    

-

U

LDHD

E

    

-

D

WDR59

E

16

16389501

16389952

43.06

+

U

NOMO3

E

    

-

D

ABCC6

E

19

19238022

19238623

13.61

+

U

CSPG3

E

    

+

D

KIAA0892

E

    

-

U

TM6SF2

E

    

-

D

HAPLN4

E

X

149544804

149545374

27.66

+

U

MTM1

I

    

+

D

MTMR1

E

    

-

U

CD99L2

E

  1. Randomly selected sequences (52) were validated by cold competition EMSAs as described in the Methods. Clones (24) with greater than 50% decrease in STAT5 DNA-binding to the [32P]-labeled probe were analyzed using CEAS. Fragments within 300 kb from coding sequences (20) are summarized above. (IDS: Immediate Downstream; U: Upstream; D: Downstream; I: Intron; E: Enhancer; chr: chromosome; dir: direction; % DNA-b.: % DNA-binding)
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Molecular Cancer

ISSN: 1476-4598