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Figure 2 | Molecular Cancer

Figure 2

From: No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue

Figure 2

Detailed structure of C-terminal part of TCF7L2 gene. A. Combinations of exons 11, 13, 13a and 14 of TCF7L2 encoding proteins with long reading frames (E-tail). B. A form with alternative exon 13 encodes a protein sequence with CRARF motif; a form with alternative exons 13a encodes a protein sequence with CRALF motif, differences in amino acids in proteins encoded by exons 13 and 13a are underlined, CRARF and CRALF motifs are boxed. C. Expression of a splicing form with exon13 correlates with MYC expression (r = 0.60, p < 10-6), while expression of a splicing form with exon 13a does not correlate with MYC expression (r = 0.15, p = 0.12).

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Molecular Cancer

ISSN: 1476-4598