Model | Cohort | Acc | PPV | NPV | Sens | Spec | P-value |
---|---|---|---|---|---|---|---|
5-GC (5 genes) | Training | 82 | 81 | 83 | 77 | 86 | 9.4 × 10-6 |
 | Validation | 79 | 100 | 78 | 22 | 100 | 0.064 |
 | COG 9404†| 75 | 71 | 76 | 36 | 93 | 0.025 |
 | POG 8704†| 68 | 83 | 66 | 29 | 96 | 0.066 |
 | Combined | 76 | 81 | 75 | 47 | 93 | 1.5 × 10 -9 (1.2 × 10 -4 ) |
Pathway NFκB (7 genes) | Training | 76 | 71 | 81 | 77 | 75 | 4.8 × 10-4 |
 | Validation | - | - | - | - | - | - |
 | COG 9404†| 77 | 83 | 76 | 36 | 97 | 0.009 |
 | POG 8704†| 56 | 44 | 59 | 24 | 79 | 1 |
 | Combined | 70 | 67 | 72 | 49 | 84 | 7.2 × 10 -5 (0.073) |
Pathway Wnt/Ca2+/cGMP (12 genes) | Training | 76 | 75 | 77 | 68 | 82 | 4.6 × 10-4 |
 | Validation | - | - | - | - | - | - |
 | COG 9404†| 75 | 67 | 77 | 43 | 90 | 0.019 |
 | POG 8704†| 68 | 63 | 72 | 59 | 75 | 0.05 |
 | Combined | 73 | 69 | 76 | 58 | 83 | 8.7 × 10 -7 (0.0011) |
Pathway Cell Adhesion (14 genes) | Training | 82 | 84 | 81 | 73 | 89 | 8.6 × 10-6 |
 | Validation | - | - | - | - | - | - |
 | COG 9404†| 75 | 62 | 81 | 57 | 83 | 0.012 |
 | POG 8704†| 85 | 87 | 85 | 76 | 92 | 1.1 × 10-5 |
 | Combined | 81 | 79 | 82 | 70 | 88 | 8.2 × 10 -12 (4.5 × 10 -7 ) |