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Table 2 NB-hypo genes

From: A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

Gene Name

GenBank*

Description

Reference†

AK3L1

NM_013410

adenylate kinase 3-like 1

[14]

ALDOC

NM_005165

aldolase C, fructose-bisphosphate

[71]

ANGPTL4

NM_016109

angiopoietin-like 4

[72]

ANKRD37

AA886870

ankyrin repeat domain 37

[73]

BHLHB2

NM_003670

basic helix-loop-helix domain containing, class B, 2

[74]

BNIP3

NM_004052

BCL2/adenovirus E1B 19 kDa interacting protein 3

[43]

BNIP3L

AF060922

BCL2/adenovirus E1B 19 kDa interacting protein 3-like

[75]

BTG1

NM_001731

B-cell translocation gene 1, anti-proliferative

[76]

DDIT4

NM_019058

DNA-damage-inducible transcript 4

[43]

E2IG5

NM_014367

growth and transformation-dependent protein

[77]

EGLN1

BC005369

egl nine homolog 1 (C. elegans)

[78]

EGLN3

NM_022073

egl nine homolog 3 (C. elegans)

[79]

FUT11

BF541967

fucosyltransferase 11 (alpha (1,3) fucosyltransferase)

--

IGF1R

H05812

insulin-like growth factor 1 receptor

[80]

IGFBP3

M31159

insulin-like growth factor binding protein 3

[81]

JMJD1A

AA524505

jumonji domain containing 1A

[82]

MAPT

AI056359

microtubule-associated protein tau

--

MTP18

AF060924

mitochondrial protein 18 kDa

--

MXI1

NM_005962

MAX interactor 1; MAX interactor 1

[83]

NDRG1

NM_006096

N-myc downstream regulated gene 1

[84]

P4HA2

NM_004199

procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha polypeptide II

[85]

PDK1

NM_002610

pyruvate dehydrogenase kinase, isoenzyme 1

[71]

PFKFB4

AL038787

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

[86]

PGK1

NM_000291

phosphoglycerate kinase 1

[87]

PGM1

NM_002633

phosphoglucomutase 1

[88]

PLOD1

NM_000302

procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1

[85]

SLC2A3

NM_006931

solute carrier family 2 (facilitated glucose transporter), member 3

[89]

TNIP1

NM_006058

TNFAIP3 interacting protein 1

--

TPI1

NM_000365

triosephosphate isomerase 1

[90]

TXNIP

AA812232

thioredoxin interacting protein

[81]

VEGF

AF022375

vascular endothelial growth factor

[71]

ZNF395

NM_017606

zinc finger protein 395

[91]

  1. * GenBank accession number.
  2. † Representative references for genes previously shown to be modulated by hypoxia.
  3. The genes that overlap with other hypoxia signatures are in bold.