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Table 4 Most differentially expressed genes between responders and non-responders to radiotherapy

From: An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients

Twenty most up-regulated genes in responders to radiotherapy

Probe set

Gene symbol

Description

FC

p-value

211538_s_at

HSPA2

Heat shock 70 kDa protein 2

3.4

< 10-4

209687_at

CXCL12

Chemokine ligand 12 (SDF1)

2.6

0.001

209480_at

HLA-DQB1

MHC complex, class II, DQ beta 1

2.5

0.023

221900_at

COL8A2

Collagen, type VIII, alpha 2

2.5

0.004

226818_at

MPEG1

Macrophage expressed gene 1

2.4

< 10-4

219759_at

ERAP2

Endoplasmic reticulum aminopeptidase 2

2.3

0.019

220146_at

TLR7

Toll-like receptor 7

2.3

0.002

222881_at

HPSE

Heparanase

2.2

< 10-4

239270_at

PLCXD3

Phosphatidylinositol-specific Phospholipase C, × domain containing 3

2.2

0.001

218858_at

DEPDC6

DEP domain containing 6

2.2

0.001

209343_at

EFHD1

EF-hand domain family, D1

2.2

0.004

205034_at

CCNE2

Cyclin E2

2.2

0.004

223170_at

TMEM98

Transmembrane protein 98

2.2

0.012

203184_at

FBN2

Fibrillin 2

2.2

0.020

1557395_at

LOC255130

 

2.2

0.035

204466_s_at

SNCA

Synuclein, alpha

2.1

0.017

228598_at

DPP10

Dipeptidyl-peptidase 10

2.1

0.023

1567628_at

CD74

CD74 molecule, MHC complex

2.1

0.006

219750_at

TMEM144

Transmembrane protein 144

2.1

0.04

228376_at

GGTA1

Glycoprotein, alpha-galactosyltransferase 1

2.1

0.006

Twenty genes most differentially up-regulated in non-responders to radiotherapy

220405_at

SNTG1

Syntrophin, gamma 1

3.4

0.001

236761_at

LHFPL3

Lipoma HMGIC fusion partner-like 3

3.2

0.035

204913_s_at

SOX11

SRY (sex determining region Y)-box 11

3.1

0.038

205230_at

RPH3A

Rabphilin 3A homolog (mouse)

2.8

0.014

202859_x_at

IL8

Interleukin 8

2.8

0.023

206201_s_at

MEOX2

Mesenchyme homeobox 2

2.7

0.047

230498_at

MCHR1

Melanin-concentrating hormone receptor 1

2.7

0.006

1554452_at

HIG2

Hypoxia-inducible protein 2

2.7

0.003

206984_s_at

RIT2

Ras-like without CAAX 2

2.6

0.023

225285_at

BCAT1

Branched chain aminotransferase 1, cytosolic

2.4

< 10-4

223278_at

GJB2

Gap junction protein, beta 2, 26kDa

2.4

0.021

205358_at

GRIA2

Glutamate receptor, ionotropic, AMPA 2

2.4

0.027

227361_at

HS3ST3B1

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

2.4

0.038

211527_x_at

VEGFA

Vascular endothelial growth factor A

2.4

0.015

219196_at

SCG3

Secretogranin III

2.3

0.025

232099_at

PCDHB16

Protocadherin beta 16

2.3

0.010

217562_at

FAM5C

Family with sequence similarity 5, member C

2.3

0.023

214920_at

THSD7A

Thrombospondin, type I, domain containing 7A

2.3

0.025

202499_s_at

SLC2A3

Solute carrier family 2 (facilitated glucose transporter), member 3

2.2

< 10-4

202912_at

ADM

Adrenomedullin

2.2

0.016

  1. List of the 20 genes most up-regulated and with a p-value <0.05 in responders versus non-responders and in non-responders versus responders to radiotherapy. FC: Fold change, p-value: Limma T-test p-value. Immune genes and hypoxia genes are underlined in responders and non-responders, respectively.
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Molecular Cancer

ISSN: 1476-4598