Table 7 Most differentially expressed genes between responders and non-responders to first-line chemotherapy
Twenty genes most up-regulated in responders to chemotherapy | ||||
|---|---|---|---|---|
Probe set | Gene symbol | Description | FC | p-value |
203296_s_at | ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 5.4 | 0.003 |
230865_at | LIX1 | Lix1 homolog (mouse) | 3.8 | 0.005 |
209728_at | HLA-DRB4 | MHC, DR beta 4 | 3.8 | 0.002 |
223075_s_at | AIF1L | Allograft inflammatory factor 1-like | 3.6 | 0.002 |
210738_s_at | SLC4A4 | Solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 3.5 | 0.02 |
223434_at | GBP3 | Guanylate binding protein 3 | 3.5 | 0.01 |
228581_at | KCNJ10 | Potassium inwardly-rectifying channel, subfamily J, member 10 | 3.4 | 0.008 |
229778_at | C12orf39 | chromosome 12 open reading frame 39 | 3.3 | 0.02 |
205143_at | NCAN | Neurocan | 3.3 | 0.02 |
225911_at | NPNT | Nephronectin | 3.3 | 0.004 |
209074_s_at | FAM107A | Family with sequence similarity 107, member A | 3.3 | 0.004 |
206306_at | RYR3 | Ryanodine receptor 3 | 3.1 | 0.04 |
217057_s_at | GNAS | GNAS complex locus | 3.1 | 0.03 |
220029_at | ELOVL2 | Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 | 3.1 | 0.008 |
1558010_s_at | SLC1A2 | Solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 3.1 | 0.01 |
223699_at | CNDP1 | Carnosine dipeptidase 1 (metallopeptidase M20 family) | 2.9 | 0.02 |
211597_s_at | HOPX | Homeodomain-only protein | 2.8 | 0.002 |
209631_s_at | GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 2.8 | 0.002 |
204379_s_at | FGFR3 | Fibroblast growth factor receptor 3 | 2.8 | 0.03 |
214279_s_at | NDRG2 | NDRG family member 2 | 2.7 | 0.008 |
Twenty genes most up-regulated in non-responders to chemotherapy | ||||
210809_s_at | POSTN | Periostin, osteoblast specific factor | 4.3 | 0.05 |
223278_at | GJB2 | Gap junction protein, beta 2, 26kDa | 4.1 | 0.01 |
231735_s_at | MALAT1 | Metastasis associated lung adenocarcinoma transcript 1 | 3.6 | 0.003 |
206785_s_at | KLRC1///KLRC2 | Killer cell lectin-like receptor subfamily C, member 1///member 2 | 3.3 | 0.03 |
230472_at | IRX1 | Iroquois homeobox protein 1 | 3.1 | 0.03 |
213350_at | RPS11 | Ribosomal protein S11 | 2.8 | 0.004 |
228367_at | ALPK2 | Alpha-kinase 2 | 2.7 | 0.01 |
209644_x_at | CDKN2A | Cyclin-dependent kinase inhibitor 2A (p16) | 2.7 | 0.04 |
221872_at | RARRES1 | Retinoic acid receptor responder (tazarotene induced) 1 | 2.6 | 0.04 |
224321_at | TMEFF2 | Transmembrane protein with EGF-like and two follistatin-like domains 2 | 2.5 | 0.004 |
225314_at | OCIAD2 | OCIA domain containing 2 | 2.5 | 0.02 |
206858_s_at | HOXC6 | Homeobox C6 | 2.5 | 0.01 |
213150_at | HOXA10 | Homeobox A10 | 2.4 | 0.04 |
235412_at | ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 2.4 | 0.03 |
209687_at | CXCL12 | Chemokine (C-X-C motif) ligand 12 | 2.3 | 0.03 |
206282_at | NEUROD1 | Neurogenic differentiation 1 | 2.2 | 0.02 |
227388_at | TUSC1 | Tumor suppressor candidate 1 | 2.2 | 0.0007 |
1562403_a_at | SLC8A3 | Solute carrier family 8 (sodium-calcium exchanger), member 3 | 2.2 | 0.02 |
201387_s_at | UCHL1 | Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 2.2 | 0.01 |
231984_at | MTAP | Methylthioadenosine phosphorylase | 2.0 | 0.0003 |