Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Table 1 Clinicopathological and genetic data of myxoid liposarcoma samples

	Sample ID	Type	Gender	Age	P/R/M	Location	FUS/DDIT3 transcript size	FUS/DDIT3 transcript type	(COBRA) FISH
1	L1187	primary culture	F	20	P	left hamstrings	1033 bp	X	t(12;16)
2	L1357	primary culture	M	50	P	left hamstrings	654 bp	I	t(12;16)
3	L1434	primary culture	F	43	P	right hamstrings	654 bp	I	t(12;16)
4	L2187	primary culture	F	42	P	left thigh, subcutaneously	378 bp	II	N/A
5	402-91	cell line	M	unknown	unknown	unknown	unknown	N/A	t(12;16)
6	1765-92	cell line	unknown	unknown	unknown	unknown	unknown	N/A	t(12;16)

Primary cultures of samples L1187, L1357, L1434 and L2187 were obtained from fresh tumors. Tumors L1187 and L1357 were high grade (> 5% round cell component), whereas L1434 and L2187 were low-grade (< 5% round cell component). These differences in grade however were not reflected in growth rate of the primary cultures (doubling times of primary cultures were all ~ 4 days; doubling times of cell lines ~ 2 days).

ISSN: 1476-4598