Figure 6From: An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivoIn vivo blood clearance rate and tumor-targeting of 125I-SLT-1AIYSNKLM (A) Blood clearance of 125I-SLT-1AIYSNKLM shown as percentage of injected dose per mL blood collected at various time points over a 72 h period post-i.v. injection. The clearance rate (t1/2) of 125I-SLT-1AIYSNKLM was shown to be ~11 min. (B) Biodistribution per collected gram of wet tissue of 125I-SLT-1AIYSNKLM after 1 h (black bars), 6 h (light grey bars), 12 h (dark grey bars) and 24 h (white bars) post-i.v. administration. (C) Tumor localization of 125I-SLT-1AIYSNKLM versus wt 125I-SLT-1A (negative control) as shown by nanoSPECT and CT imaging. The composite images show the tissue uptake of the radiolabeled proteins (as pink colored areas) as well as the location of tumor xenografts (white circles) and that of kidneys (grey arrows).Back to article page