Figure 4From: Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesisTumorigenicity of R2d and R2N1d cells, and genes expressed by tumors developed by R2N1d cells. A, the development of tumors in immune-deficient mice after inoculation with different numbers of R2d or R2N1d cells (1 × 105, 1 × 106 or 1 × 107 cells per site) for 4 months (R2d) or 4 weeks (R2N1d). The average size of tumors for each treatment are also determined. B, histological sections of resected tumor revealed sheets of polygonal cells with high nucleus/cytoplasm (N/C) ratio. C, these tumor cells expressed Ki67 (90%), VEGF (score 4), COX-2 (score 4) and MMP-9 (score 4). The length of the scale bar of these photos is 100 μm.Back to article page