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Figure 9 | Molecular Cancer

Figure 9

From: Human homolog of Drosophila H airy and e nhancer of s plit 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer

Figure 9

Inhibition of γ-secretase altered PC3 cell cycle progression and increased cellular processes. (A) Percentage of cell populations in each cell cycle stages (G1, S, G2/M and SubG1) of PC3 cells treated with or without γ-secretase inhibitors (DAPT or WPE-III-31C). * p < 0.05. (B-D) Morphology of PC3 cells treated for 48 hours with DMSO (B, control), DAPT (C) or WPE-III-31C (D). Note: Inhibition of γ-secretase showed increased number of cells with elongated shape or with extended cellular protrusions (Arrows) in PC3 cells (C and D). 31C: WPE-III-31C. Three independent experiments were performed. Bar: 50 μm.

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Molecular Cancer

ISSN: 1476-4598