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Table 1 Tumor panel with integrations in the Cd74 locus

From: A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNγ-inducible Cd74 isoform

Tumor ID and tissuea

Virus variantb

Lymphomagenic potential of virus variant

Lymphoma incidence n/total

Mean latency in daysc

Latency in daysd

01-340s

Akv wt

Be

36/39

185 ± 26

194

01-367s

Akv wt

Be

36/39

185 ± 26

190

01-617s

Akv wt

Be

36/39

185 ± 26

251

99-919m

Akv1-99 wt

Be

67/70

181 ± 26

150

99-1206c

Akv1-99 wt

Be

67/70

181 ± 26

209

01-454s

Akv1-99 wt

Be

67/70

181 ± 26

198

99-34m

Akv PBS-Arg

Bf

19/19

178 ± 17

172

99-162c

Akv PBS-Gln

Bf

23/23

182 ± 27

204

99-18m

Akv PBS-Lys

Bg

19/20

206 ± 30

172

99-115c

Akv PBS-Lys

Bg

19/20

206 ± 30

204

99-191t

Akv PBS-Lys

Bg

19/20

206 ± 30

225

98-1130s

Akv PBS-Pro

Bf

20/20

161 ± 36

131

01-1064s

Akv1-99 (mAML1+mEgre)

Bh

45/46

199 ± 35

232

01-671s

Akv1-99 (mEts)

Bh

43/44

182 ± 27

163

01-700s

Akv1-99 (mEts)

Bh

43/44

182 ± 27

169

01-762s

Akv1-99 (mEts)

Bh

43/44

182 ± 27

177

01-931s

Akv1-99 (mEts)

Bh

43/44

182 ± 27

204

99-1159s

Akv1-99NF1m1

Bi

16/17

187 ± 19

199

01-656s

Akv1-99NF1m2

Bi

44/44

182 ± 28

156

01-696s

Akv1-99NF1m2

Bi

44/44

182 ± 28

162

01-785c

Akv1-99NF1m2

Bi

44/44

182 ± 28

177

01-815c

Akv1-99NF1m2

Bi

44/44

182 ± 28

181

01-843s

Akv1-99NF1m2

Bi

44/44

182 ± 28

184

01-1067s

Akv1-99NF1m2

Bi

44/44

182 ± 28

218

01-1069s

Akv1-99mEa/s

Bh

47/47

165 ± 23

183

01-844s

Akv1-99mEa/s

Bh

47/47

165 ± 23

149

01-898s

Akv1-99mEa/s

Bh

47/47

165 ± 23

158

99-306t

SL3-3(AML1dm)

Mixed, incl. B j

36/42

NA

175

01-552s

Akv1-99 (mAML1)

Bh

43/45

126 ± 40

162

01-720s

Akv1-99 (mEgre)

Bh

50/50

148 ± 47

185

03-462s

Akv1-99 (mEgre)

Bh

41/42

160 ± 27

154

01-773s

Akv1-99 (mAML1+mGR)

Bh

53/53

190 ± 31

203

01-1062m

Akv1-99 (mAML1+mGR)

Bh

53/53

190 ± 31

245

03-741s

Akv1-99 (mEgre+mEa/s)

Bh

41/41

183 ± 38

199

01-930s

Akv1-99 (mEts)

Bh

43/44

182 ± 27

204

03-793s

Akv1-99 (mGr)

Bh

40/41

145 ± 28

164

00-140n

Akv SA' gag mutant (EH)

Bk

17/18

184 ± 34

205

00-111n

Akv SA' gag mutant (CD)

Bk

17/19

201 ± 30

188

02-1156m

Akv/SL3-3TM

Ongoing work

23/23

139 ± 23

115

03-1160s

Akv1-99 (mGR+mEa/s)

Bh

46/49

186 ± 26

240

00-216m

Akv SA' gag mutant (EH)

Bk

17/18

184 ± 34

232

99-1276s

Akv SA' gag mutant (CDH)

Bk

14/16

190 ± 46

163

  1. aS indicates spleen; m, mesenteric lymph node; c, cervical lymph nodes; t, thymus; and n, lymph node of unspecified position. bIndicate the MLV injected into inbred NMRI mice for tumor induction. cIndicates the mean latency for tumor induction in mice infected with the same MLV as the one giving rise to the listed tumor with integration in Cd74. dIndicates the age of the mouse harboring the listed tumor at the point of cervical dislocation and tumor isolation. The pathogenic potential of these viruses were determined in the following studies; e[41], f(Unpublished), g[48], h[46], i[68], j[44], and k[67].
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Molecular Cancer

ISSN: 1476-4598