Figure 1

NGS MACE profiles discriminate PDAC from healthy control tissues. A) Unsupervised hierarchical cluster analysis of differentially expressed genes with euclidean distance measure clearly separates healthy controls (N) and diseased patients (P). (B) Principle component analysis (PCA) of all genes from the eleven samples under scrutiny. The first (x-axis) and second principal component (y-axis) account for 32% and 18%, respectively, of the total variation in the data. (C) Pearson product–moment correlation coefficient (PCC) for all samples compared within the control and patient group as well as between both groups.