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Table 4 Significantly up- and downregulated sncRNAs

From: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

a) Downregulated in PDAC

     

sRNA

NEV normal

NEV PDAC

Log2 FoldChange

FDR

Previously shown

hsa-miR-216b

57,650.3

99.6

9.2

0.0000000

[7,8,11]

hsa-miR-216a-3p

3,218.9

4.1

9.6

0.0000000

[7,8,11]

hsa-miR-217

86,322.3

143.1

9.2

0.0000000

[7-9,11]

hsa-miR-216a-5p

35,959.9

144.7

8.0

0.0000000

[7-9,11]

hsa-miR-802

3,702.2

2.0

10.9

0.0000000

-

hsa-miR-148a-5p

4,252.9

178.9

4.6

0.0000000

[7-9,11]

hsa-miR-2114-5p

88.5

0.9

6.6

0.0000000

-

hsa-miR-375

121,790.3

11,992.2

3.3

0.0000001

[7-9,11]

hsa-miR-130b-5p

890.4

95.1

3.2

0.0000002

[7-9,11]

hsa-miR-148a-3p

224,094.2

25,764.7

3.1

0.0000005

[7-9,11]

hsa-miR-130b-3p

3,038.0

395.2

2.9

0.0000008

[7-9,11]

hsa-miR-190b

436.6

19.5

4.5

0.0000026

-

hsa-miR-2114-3p

44.7

0.3

7.0

0.0000270

-

hsa-sno-HBII-296B

1,159.5

208.8

2.5

0.0000525

-

hsa-miR-30c-2-3p

164.1

27.1

2.6

0.0000657

[7-12]

hsa-miR-219-5p

219.7

36.4

2.6

0.0000808

[7]

hsa-piR-017061

4,818,0

951,7

2,3

0.0001447

-

hsa-miR-30a-3p

1,350.4

275.0

2,3

0.0001447

[7-9,12]

hsa-miR-29c-3p

41,297.8

8.131.4

2,3

0.0003007

[7-9,12]

hsa-sno-U104

7,726.4

1.703.0

2,2

0.0007282

-

b) Upregulated in PDAC

     

hsa-miR-135b-3p

1.2

80.9

−6.1

0.0000000

[11,12]

hsa-miR-135b-5p

948.9

9,475.0

−3.3

0.0000002

[11,12]

hsa-miR-21-3p

174.6

2,117.3

−3.6

0.0000005

[7-12]

hsa-miR-708-5p

309.2

3,100.3

−3.3

0.0000022

[7,10]

hsa-miR-615-3p

1.2

97.2

−6.3

0.0000024

[7]

hsa-miR-34c-5p

47.5

475.2

−3.3

0.0000048

[11]

hsa-miR-431-5p

7.0

99.7

−3.8

0.0000062

-

hsa-miR-511

17.1

242.6

−3.8

0.0000079

-

hsa-miR-143-5p

238.7

2,089.8

−3.1

0.0000092

[7-10,12]

hsa-miR-222-3p

2,263.7

17,399.2

−2.9

0.0000131

[7-12]

hsa-miR-34c-3p

2.7

49.7

−4.2

0.0000210

-

hsa-miR-155-5p

392.4

3,458.7

−3.1

0.0000210

[7-10,12]

hsa-miR-24-2-5p

396.5

2,965.3

−2.9

0.0000407

[9,10,12]

hsa-miR-34b-3p

1.0

29.5

−4.9

0.0000681

[7,9]

hsa-miR-708-3p

24.4

188.7

−3.0

0.0001073

[7,10]

hsa-miR-223-5p

17.4

204.8

−3.6

0.0001117

[7-10,12]

hsa-miR-34b-5p

12.5

96.7

−3.0

0.0001145

[7,9,11]

hsa-miR-10a-3p

101.1

643.8

−2.7

0.0001447

[7-10]

hsa-miR-196b-5p

10.1

738.0

−6.2

0.0001832

[9,11]

hsa-miR-2355-3p

3.8

43.2

−3.5

0.0002933

-

  1. For the 20 most significantly up- and downregulated sncRNAs the mean normalized expression values (NEV) for each group is provided together with the ratio between normal and PDAC expression in log2 scale (log2FoldChange). In addition, the column “previously shown” indicates if other groups have provided evidence for the deregulation of the RNA before.
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Molecular Cancer

ISSN: 1476-4598