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Fig. 6 | Molecular Cancer

Fig. 6

From: Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients

Fig. 6

Summary of alterations in molecular, cellular and functional features of HNSCC cells after loss of KLK6 expression. Silencing of KLK6 expression induces an EMT-like phenotype characterized by loss of E-cadherin and gain of Vimentin expression (indicated in green) as well as nuclear accumulation of β-catenin (indicated in red). As a consequence, KLK6-negative tumor cells exhibit increased proliferation, motility and radioresistance, which is in line with the poor clinical outcome of HNSCC patients with low KLK6 expression

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Molecular Cancer

ISSN: 1476-4598