Fig. 2

Comparison of the score with prognostic clinical covariates. Multivariable Cox regression proportional hazards regression analyses incorporating the risk score and known prognostic clinical factors, including age at diagnosis, TNM stage (I, II, III, IV) and gender; risk score and age as continuous variables, TNM stage and gender as categorical variables. Solid tetragonums represent the HR of death and open-ended horizontal lines represent the 95 % confidence intervals (CIs). All P values were calculated using Cox proportional hazards analysis. a Multivariable analysis was performed using Cox proportional hazards regression analysis in patients of GSE62254 test series. b Multivariable analysis was performed using Cox proportional hazards regression analysis in patients of GSE62254 validation series. c Multivariable analysis was performed using Cox proportional hazards regression analysis in patients of entireGSE62254 series. d Multivariable analysis was performed using Cox proportional hazards regression analysis in patients of GSE15459 series. All of these were adjusted for the same categorical or continuous variables. Missing: HR (95 % CI) could not be calculated out