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Fig. 11 | Molecular Cancer

Fig. 11

From: Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells

Fig. 11

MCF-7 MT1-MMP C3 cells displayed high tumorigenic potential when implanted onto the avian embryo CAM. MCF-7 MT1-MMP cell lines and MDA-MB 231 cells stably expressing zsGreen were implanted into the CAM of day 9 ex ovo chicken embryos and visualized 8 days post –implantation using a fluorescence stereoscope to analyze tumor vascularization. Displayed are representative bright field images showing the area of implantation on the embryo, and respective fluorescent images showing the zsGreen channel. The white boxes outline the insets showing vascularization of the MT1-MMP C3 and MDA-MB 231 tumours. Bar graph shows percentage of tumours that were vascularized (N ≥ 11). Scale bars = 2 mm

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Molecular Cancer

ISSN: 1476-4598