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Fig. 5 | Molecular Cancer

Fig. 5

From: Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling

Fig. 5

Inhibitory effects of BJ-1113 on 5-HT-induced invasion and proliferation of MDA-MB-231 cells. a Chemical structure of BJ-1113. b Treatment of MDA-MB-231 cells and HCC-1395 cells with BJ-1113 concentration-dependently suppressed 5-HT-induced invasion. c Measurements of MDA-MB-231 proliferation in the absence or presence of BJ-1113. d Serum-induced MDA-MB-231 cell proliferation was significantly inhibited by BJ-1113, and this was greater than the inhibition observed for SB269970. e BJ-1113 suppressed serum-induced proliferation in HCC-1395, TNBC cells but not in MCF-10A normal breast cells. f Western blot analyses of 5-HT-induced TPH1, MMP-9 and VEGF expressions in BJ-1113-treated MDA-MB-231 cells. *P < 0.05 vs. vehicle-treated controls. # P < 0.05 vs. 5-HT-treated cells

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Molecular Cancer

ISSN: 1476-4598