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Table 3 Mapping of mutations to chosen CRRs proximal and distal to the transcription start site

From: Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data

 

Proximal (<10kB from TSS)

Distal (>10kB from TSS)

Mean mutations/CRR (all models)

2.301

1.251

Mean mutations/CRR (cancer related transcripts)

3.402

0.992

  1. 1Mean greater in proximal set, p < 10−39 (t-test), p < 10−17 (Wilcoxon)
  2. 1Mean greater in proximal set, p < 10−6 (t-test), p < 0.05 (Wilcoxon)
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Molecular Cancer

ISSN: 1476-4598