Fig. 3
From: Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells
p38 and p42/44 MAPK signaling pathways regulate IL1-mediated OPG secretion in breast cancer cells. a Relative OPG mRNA and b OPG secreted protein levels measured 24 h after the simultaneous treatment of IL1B (10 ng/mL) and MAPK inhibitor(s) (10 μM) of p38 (SB202190, SB203580), p42/44 (U0126, BAY869766), and JNK (SP600125)) (n ≥ 3) in BT549, ZR75-1 and SKBR3 breast cancer cell lines. Data are represented by mean ± SD. ^ denotes p < 0.05, as compared to DMSO; asterisks denotes p < 0.05, as compared to DMSO + IL1B