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Fig. 6 | Molecular Cancer

Fig. 6

From: Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

Fig. 6

Impact of glutamine deprivation and H2O2 on β-catenin pathway. a A549 cells were cultured in RPMI 1640 medium without glutamine for the indicated time, and cell lysates were subjected to western blotting to measure the expression of SOX2, p-β-catenin, β-catenin, and β-actin. b A549 cells were treated 100 μM H2O2 for the indicated time, and cell lysates were subjected to western blotting to measure the expression of SOX2, p-β-catenin, β-catenin and β-actin. c Expression of β-catenin and ABCG2 mRNA in A549 cells transfected with siRNA against β-catenin or with negative control siRNA (NC). *, p < 0.05; ***, p < 0.001. d Expression of β-catenin and ABCG2 protein in A549 cells after siRNA silencing of β-catenin

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Molecular Cancer

ISSN: 1476-4598