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Fig. 7 | Molecular Cancer

Fig. 7

From: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Fig. 7

CXCL5/CXCR2 promotes CRC liver metastasis in vivo and schematic diagram. a & c Representative images of liver metastasis in the indicated HCT116 and SW480 cells in vivo. Scale, 100 μm. Six mice are included in each group. b & d The number of metastatic nodules in each indicated group. Data are presented as the mean ± SD. *P < 0.05, ***P < 0.001. e Schematic diagram shows that tumor-derived CXCL5 promotes CRC cell migration by inducing EMT through the activation of ERK/Elk-1/Snail and enhances invasion through the activation of AKT/GSK3β signaling, which inhibits the degradation of β-catenin. Accumulated β-catenin in the cytoplasm translocates to the nucleus to promote the expression of MMP7, which facilitates cell invasion

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Molecular Cancer

ISSN: 1476-4598