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Fig. 8 | Molecular Cancer

Fig. 8

From: Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Fig. 8

A schematic diagram for the mechanisms underlying PXR-regulated MRP3-mediated resistance. PXR enhances the resistance of tumor cells to the chemotherapeutic agent L-OHP via direct transcriptional activating MRP3 expression, increasing the L-OHP efflux capacity of tumor cells in CRC

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Molecular Cancer

ISSN: 1476-4598