Table 2 Structural formulas of PI3K inhibitors
Classification | Compound | Structural formula | Compound | Structural formula |
|---|---|---|---|---|
Pan-PI3K inhibitors | Pictilisib (GDC-0941) |
| Copanlisib (BAY 80–6946) |
|
Taselisib (GDC-0032) |
| Sonolisib (PX-866) |
| |
Buparlisib (BKM120) |
| ZSTK474 |
| |
Pilaralisib (XL147, SAR245408) |
| AMG 511 |
| |
Isoform-selective inhibitors | Alpelisib (BYL719) |
| CH5132799 |
|
Idelalisib (CAL-101, GS-1101) |
| AS-605240 |
| |
AMG319 |
| MLN1117 (INK1117) |
| |
AZD6482 |
| Â | Â | |
Dual PI3K/mTOR inhibitors | Dactolisib (NVP-BEZ235) |
| GDC-0084 (RG7666) |
|
NVP-BGT226 |
| VS-5584 (SB2343) |
| |
Omipalisib (GSK2126458, GSK458) |
| PF-04691502 |
| |
GSK1059615 |
| Gedatolisib (PF-05212384, PKI-587) |
| |
Voxtalisib (XL765, SAR245409) |
| PQR309 |
| |
Apitolisib (GDC-0980) |
| Â | Â |
