Table 1 LncRNAs with a role in several cancers of the female reproductive system
From: Dysregulated expression of long noncoding RNAs in gynecologic cancers
LncRNA | Size (kb) | Locus | Mechanism | Nature | Related cancer | Ref |
|---|---|---|---|---|---|---|
MALAT1 | 8 | 11q13.1 | Strong activation of wnt/beta-catenin signaling pathway through loss of PCDH10 tumor suppressor | Oncogene | Endometrial Carcinoma | [60] |
1- Promotes motility and invasion Increases snail expression; or via MALAT1/miR-124/RBG2 signaling 2-Inhibits cell apoptosis Regulates caspase-3, caspase-8, Bax, Bcl-2, and BclxL 3- Involved in radio-resistance Represses miR-145 reciprocally | Oncogene | Cervical Cancer | ||||
Correlated with apoptosis and tumorigenicity | Oncogene | Ovarian Cancer | [135] | |||
HOTAIR | 2.2 | 12q13.13 | Estradiol-responsive gene induced by estradiol, estrogen receptors and general transcription factors of RNA polymerase II | Oncogene | Endometrial Carcinoma | |
Correlates with migration and invasion | Oncogene | Ovarian Cancer | ||||
Increases cell migration and invasion | Oncogene | Cervical Cancer | ||||
H19 | 2.3 | 11p15.5 | Imprinting | Oncogenic | Endometrial Carcinoma | |
Imprinting | Oncogenic | Cervical Cancer | [140] | |||
Correlates with migration and invasion | Oncogene | Ovarian Cancer | ||||
MEG3 | 1.6 | 14q32.2 | Positive regulator of p53 | Tumor suppressor | Ovarian Cancer | [34] |
1- Inhibits cell growth Induce G2/M cell cycle arrest and apoptosis 2- Inhibits proliferation and enhances apoptosis. Decreases miR-21-5p levels | Tumor suppressor | Cervical Cancer | ||||
CCAT2 | 0.34 | 8q24.21 | Correlates with tumor invasion, migration and cell proliferation | Oncogene | Ovarian Cancer | [98] |
Correlates with tumor metastasis | Oncogene | Cervical | [143] | |||
ANRIL | 3.8 | 9p21.3 | Correlates with metastasis, cell proliferation both in vitro and in vivo, promotion of cell cycle progression and inhibition of apoptosis and senescence | Oncogene | Ovarian Cancer | |
Facilitates proliferation by inhibition of p15 | Oncogene | Cervical Cancer | [104] | |||
OVAL | 1.4 | 1q25 | Upregulated altogether with p53-regulated genes | Oncogene | Endometrial Carcinoma | [105] |
Not described | Oncogene | Ovarian Cancer | [105] | |||
BC200 | 0.2 | 2p21 | Translational modulator and correlated with proliferation and chemoresistance | Oncogene | Ovarian Cancer | [121] |
Not studied | Oncogene | Cervical Cancer | [122] | |||
CUDR | 2.2 | 19p13.12 | Involved in drug resistance | Oncogene | Cervical Cancer | [111] |
Involved in drug resistance | Oncogene | Ovarian Cancer | [107] |