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Table 1 Alteration of Oct4, NEAT1 and MALAT1 expression levels in relation to clinicopathological parameters in 124 lung cancer patients

From: Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Characteristics

 

Oct4

 

NEAT1

 

MALAT1

 

Total

Normal

Overexpression

 

Normal

Overexpression

 

Normal

Overexpression

 

n

n

(%)

n

(%)

P a

n

(%)

n

(%)

P a

n

(%)

n

(%)

P a

Overall

124

18

(14.5)

106

(85.5)

 

12

(9.7)

112

(90.3)

 

14

(11.3)

110

(88.7)

 

Tumor stage

 I + II

72

16

(22.2)

56

(77.8)

0.005

11

(15.3)

61

(84.7)

0.014

12

(16.7)

60

(83.3)

0.028

 III + IV

51

2

(3.9)

49

(96.1)

 

1

(2.0)

50

(98.0)

 

2

(3.9)

49

(96.1)

 

T stage

 I + II

104

18

(17.3)

86

(82.7)

0.050

11

(10.6)

93

(89.4)

0.473

13

(12.5)

91

(87.5)

0.361

 III + IV

19

0

(0.0)

19

(100.0)

 

1

(5.3)

18

(94.7)

 

1

(5.3)

18

(94.7)

 

N stageb

 0

71

15

(21.1)

56

(78.9)

0.021

11

(15.5)

60

(84.5)

0.014

12

(16.9)

59

(83.1)

0.029

 1 + 2

50

3

(6.0)

47

(94.0)

 

1

(2.0)

49

(98.0)

 

2

(4.0)

48

(96.0)

 

M stagec

 0

116

18

(15.5)

98

(84.5)

0.259

12

(10.3)

104

(89.7)

0.370

14

(12.1)

102

(87.9)

0.329

 1

7

0

(0.0)

7

(100.0)

 

0

(0.0)

7

(100.0)

 

0

(0.0)

7

(100.0)

 

NEAT1

 Normal

12

10

(83.3)

2

(16.7)

<0.001

−

−

−

−

−

−

−

−

−

 

 Overexpression

112

8

(7.1)

104

(92.9)

 

−

−

−

−

 

−

−

−

−

 

MALAT1

 Normal

14

10

(71.4)

4

(28.6)

<0.001

11

(78.6)

3

(21.4)

<0.001

−

−

−

−

 

 Overexpression

110

8

(7.3)

102

(92.7)

 

1

(0.9)

109

(99.1)

 

−

−

−

−

 
  1. aThe data were analyzed by Pearson χ2 test. Bold values indicate statistical significance (P < 0.05)
  2. bN Stage: lymph node metastasis
  3. cM Stage: distant metastasis
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Molecular Cancer

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