Fig. 4From: The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapyThe regulation network of microenvironment-derived EVs as well as H.pylori-derived EVs in GC. EVs secreted by CAF, MSC, and TAM induce GC progression through different pathways and molecules. H.pylori releases CagA-containing EVs and other EVs that inhibit T cell responses, active monocytes to induce COX-2 expression, and active TAM to induce gastric carcinogenesis. Abbreviations: TAM, tumor-associated macrophage; CAF, cancer-associated fibroblast; MSC, mesenchymal stem cellBack to article page