Skip to main content
Fig. 7 | Molecular Cancer

Fig. 7

From: Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma

Fig. 7

5mC and m6A regulators cooperatively enhance DNA damage repair and cell cycle progression in HCC. A Heatmap of the activity of the 50 well-defined biological states or processes in the high- and low-EME patients. B Associations between the EME and DNA damage repair, and cell cycle pathways. C Heatmap of the activity of DNA damage repair pathways in the high- and low-EME patients. D Associations between the EME and DNA damage repair pathways. E GSEA of DNA damage repair pathways for the high- and low-EME patients. F–H Flow cytometry for cell cycle distribution of HCC cells with si-DNMT1 or/and si-METTL3. Ns: no significance; *p-value < 0.05; **p-value < 0.01; ***p-value < 0.001; ****p-value < 0.0001

Back to article page

Molecular Cancer

ISSN: 1476-4598