Fig. 4
From: LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer
KCNQ4 is a downstream target gene of BC069792. a RT-qPCR results showed that overexpression of BC069792 affected the expression of multiple genes in MDA-MB-231 cells, among which the increase of KCNQ4 was the most significant. b Western blot showed that the expression of KCNQ4 protein in the BC069792 overexpression group was significantly higher than that in the control group (MDA-MB-231: P = 0.0271, MDA-MB-468: P = 0.0088). c The mRNA expression of KCNQ4 in normal breast tissue was significantly higher than that in breast cancer tissue (P = 0.0145). d The protein expression of KCNQ4 in normal breast tissue was significantly higher than that in breast cancer tissue (P = 0.031). e and f In axillary tumors of mice, the expression of mRNAand protein of KCNQ4 in LV-BC069792 group was significantly higher than that in LV-NC group. g and h In lung metastasesof mice, the expression of mRNAand proteinof KCNQ4 in LV-BC069792 group was significantly higher than that in LV-NC group. i The content of KCNQ4 protein in LV-BC069792 tumor tissues of nude mice was significantly higher than that in LV-NC nude mice (P = 0.0051). j In human tumor tissue and nude mouse tumor tissue, BC069792 and KCNQ4 had a significant positive correlation. k BC069792 can promote the RNA stability of KCNQ4.(P < 0.05, P < 0.01, P < 0.001,.P < 0.0001, ns represent P > 0.05)**********