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Fig. 2 | Molecular Cancer

Fig. 2

From: m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

Fig. 2

Clonal evolutionary trajectory of metastatic LUAD cells. A The single cell atlas showing tumor cell subpopulations. B Dotted line graph showing the ratio of distinct tumor cell subpopulations in control, primary and metastatic LUAD. C The single-cell atlas mapping the expression of FAM83A and IGF2BP2 in tumor cells. D Fluorescence assay-fluorescent probe assay showing IGF2BP2 in LUAD tissues with high or low CD34 expression. Bar, 50 μm. E Volcano map showing differentially expressed genes in malignant cells and their subpopulations between metastatic and primary LUAD. F The single-cell atlas mapping the pseudotime values and evolutionary trajectory. G Evolutionary tree showing the evolutionary trajectory of tumor cells. H Heat map-pathway showing signaling pathways involved in temporally relevant genes

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Molecular Cancer

ISSN: 1476-4598