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Fig. 6 | Molecular Cancer

Fig. 6

From: The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications

Fig. 6

Neutrophil clearance. In cancer, the clearance of neutrophils is also mediated by key signaling molecules. This process exhibits distinct characteristics in both the tissue and circulation [36]. Aged neutrophils, which have a shorter lifespan, express increasingly high levels of CD16, CXCR4, CD10, and CD11b. They can either be recruited back into the bone marrow through a CXCR4/CXCL12-dependent pathway or be eliminated by macrophages in peripheral tissues [142,143,144]

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Molecular Cancer

ISSN: 1476-4598