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Fig. 8 | Molecular Cancer

Fig. 8

From: A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis

Fig. 8

The cartoon showing the promoting effect of circ-YAP on CRC liver metastasis through translating into a novel YAP isoform, YAP-220aa, in an m6A-dependent manner; subsequently, YAP-220aa directly binds to LATS1 and blocks the interaction between LATS1 and YAP, resulting in YAP nuclear translocation and transcription activation of pro-metastasis genes and circ-YAP, thus forming a positive regulatory loop

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Molecular Cancer

ISSN: 1476-4598