Tumor type | Sample type | CAF Phenotype | Biomarker(s) | Ref | |
---|---|---|---|---|---|
Pancreatic ductal adenocarcinoma | Patient, KPC mouse | myCAF | α-SMAHigh, FAP | ||
iCAF | IL-6, IL11, α-SMALow, PDGFRαHigh | ||||
apCAF | MHCII, CD74 | ||||
Breast cancer and ovarian cancer | Patient | CAF-S1 | CD29Med FAPHigh FSP1Low−High α-SMAHigh PDGFRbMed−High CAV1Low | ||
CAF-S2 | CD29Low FAPNeg FSP1Neg−Low α-SMANeg PDGFRbNeg CAV1Neg | ||||
CAF-S3 | CD29Med FAPNeg FSP1Med−High α-SMANeg−Low PDGFRbMed CAV1Neg−Low | ||||
CAF-S4 | CD29High FAPNeg FSP1Low−Med α-SMAHigh PDGFRbLow−Med CAV1Neg−Low | ||||
Breast cancer | Patient | cluster 0 (ECM-myCAF) | LRRC15, GBJ2 | [93] | |
cluster 1 (detox-iCAF) | ADH1B, GPX3 | ||||
cluster 2 (IL-iCAF) | RGMA, SCARA5 | ||||
cluster 3 (TGFβ-myCAF) | CST1, TGFb1 | ||||
cluster 4 (wound-myCAF) | SEMA3C, SFRP4 | ||||
cluster 5 (IFNg-i CAF) | CCL19, CCL5 | ||||
cluster 6 (IFNab-myCAF) | IFIT3, IRF7 | ||||
cluster 7 (acto-myCAF) | GGH, PLP2 | ||||
Breast cancer | Patient | CAF +  | ADAMTS12High, AEBP1High, COL10A1High, COL11A1High, EDNRAHigh, EPPK1High, WNT7B High, CXCL11Low, CXCR6Low | [82] | |
CAF- | ADAMTS12Low, AEBP1Low, COL10A1 Low, COL11A1Low, EDNRALow, EPPK1Low, WNT7B Low CXCL11 High, CXCR6High | ||||
Breast cancer | Murine | vCAF | FAP, S100a4, ACTA2, PDGFRβ | [83] | |
mCAF | FAP, S100a4, ACTA2, PDGFRα | ||||
cCAF | FAP, S100a4, ACTA2, PDGFRβ | ||||
dCAF | FAP, Sox9, Sox10, PDGFRβ | ||||
Solid tumors | Murine and human | SSL CAF | Cluster 1 | Pi16, Dpp4, Dpt, CD34 | [86] |
Cluster 3 | Pi16, Dpp4 | ||||
MR CAF | Cluster 2 | FAK | |||
Cluster 4 | Lrrc15, Spp1 | ||||
Cluster 5 | Thbs 2, FSP 1, Col 6a 1, Cdh 11 | ||||
IM CAF | Cluster 0 | IL 1, IFNg, CXCL12 | |||
Gastric cancer | Patient | iCAF | IL6, CXCL12 | [96] | |
eCAF | MMP14, LOXL2, POSTN | ||||
Colorectal cancer | Human | CAF-A | FAP, MMP2, DCN | ||
CAF-B | α-SMA, PDGFA, TAGLN | ||||
Lung cancer | Patient | subtype I | HGFHigh FGF7High/Low p-SMAD2Low | [87] | |
subtype II | HGFLow FGF7High p-SMAD2Low | ||||
subtype III | HGFLow FGF7Low p-SMAD2High | ||||
Lung cancer | Patient | Cluster1 | COL10A1 | [88] | |
Cluster2 | COX4I2 | ||||
Cluster3 | – | ||||
Cluster4 | PLA2G2A | ||||
Cluster5 | MMP3 | ||||
Cluster6 | FIGF | ||||
Cluster7 | – | ||||
Metastatic lymph nodes | Patient | CAF-S1 | FAPHigh CD29Med−High αSMAHigh PDPNHigh PDGFRβHigh; | [89] | |
CAF-S2 | FAPNeg CD29Low αSMANeg−Low PDPNLow PDGFRβLow | ||||
CAF-S3 | FAPNeg−Low CD29Med αSMANeg−Low PDPNLow PDGFRβLow−Med | ||||
CAF-S4 | FAPLow−Med CD29High αSMAHigh PDPNLow PDGFRβMed | ||||
Ovarian cancer | Patient | CAF_c1 | CCDC80, SFRP2, VCAN, COL8A1 | [90] | |
CAF_c2 | RGS5, NOTCH3, NDUFA4L2 | ||||
Melanoma, head and neck squamous cell carcinoma, and lung cancer | Patient | Pan-CAF 1(pan-myCAFs) | ACTA2, MYH11, MCAM, TAGLN | [91] | |
Pan-CAF 2(pan-dCAFs) | COL1A1, COL3A1 | ||||
Pan-CAF 3(pan-iCAFs) | CFD, CXCL14, CXCL12 | ||||
Pan-CAF 4(pan-iCAFs-2) | CXCL2 | ||||
Pan-CAF 5(pan-nCAF) | CXCR4, NCAM1 | ||||
Pan-CAF 6(LQ-CAF) | C10orf10 | ||||
Pan-CAF 7(pan-pCAF) | BIRC5, TOP2A |