Table 3 Assay Positive Predictive Value, Negative Predictive Value, Specificity, Sensitivity, and Concordance of TP53 pathogenic variant on acfDNA compared With Tumor Tissue
From: Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
AcfDNA Positive sample | acfDNA negative sample | Sensitivity, | Specificity, | Concordance, | Cohen K, | |
|---|---|---|---|---|---|---|
%(95%,CI) | %(95%,CI) | % | (P value) | |||
Tissue | 35 | 1 | ||||
Positive | 97 | 83 | 95 | 0,81 | ||
Tissue | 1 | 5 | (86–100) | (43 – 100) | (< 0,001) | |
Negative |