Manufacturing Method | Scale | Cost | Quality Control | Yield | Flexibility | References |
---|---|---|---|---|---|---|
Emulsion | Small | Low | High | Low | High | [117] |
Nanoprecipitation | Medium | Moderate | Moderate | Moderate | High | [118] |
Microfluidics | Small | High | High | High | High | [118] |
Electrospinning | Small | High | High | High | Low | [118] |
Self-Assembly | Medium | High | Low | High | Moderate | [119] |
Spray Drying | Large | Moderate | Low | High | Low | [120] |
Solvent Casting | Large | Moderate | High | Moderate | Moderate | [120] |
Superparamagnetic Iron Oxide Nanoparticle Synthesis by Co-precipitation | Small | Low | High | High | Low | [121] |
Microemulsion Method for Solid Lipid Nanoparticle Synthesis | Small | Moderate | High | Moderate | High | [57] |
Flash NanoPrecipitation for Polymer Nanoparticle Synthesis | Medium | High | High | High | High | [122] |
Hydrodynamic Focusing Microfluidics for Liposome Synthesis | Small | High | High | High | High | [123] |
Electrospray for Protein Nanoparticle Synthesis | Small | High | High | Low | High | [100] |
Ultrasonic Atomization for Polymeric Micelle Synthesis | Medium | Moderate | Moderate | Moderate | Moderate | [123] |
Hot Melt Extrusion for Lipid Nanoparticle Synthesis | Large | High | High | High | Moderate | [57] |
Flash Nanocomplexation for RNA Nanoparticle Synthesis | Medium | High | Moderate | High | High | [100] |