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Fig. 1 | Molecular Cancer

Fig. 1

From: A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer

Fig. 1

Construction of the 22-gene signature. A Heatmap of 340 genes which were differentially expressed between different BOR (patients with CR + PR versus PD + SD) in the training cohort. Each column represents an individual sample, and each row represents a gene. P < 0.05. *The TPM values centered and scaled in the row direction by R package ‘pheatmap’. B The ranking and selection of BOR associated variates using the random forest algorithm. C, D The most robust predictive 22 genes were identified using LASSO-logistic algorithm

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Molecular Cancer

ISSN: 1476-4598