Effects of RNA methylation on Tumor angiogenesis and cancer progression

Table 1 The functions of m6A enzymes in the angiogenesis of various cancers

Type	Molecule	Role in tumors	Tumor type	Mechanism	References
Writers	METTL3	Oncogene	Bladder cancer	Promote angiogenesis via modulating TEK and VEGF-A	[72]
		Oncogene	GC	Promote angiogenesis via stimulating m6a modification of HDGF mRNA	[58]
		Oncogene	HCC	Promote angiogenesis via modulating Hippo pathway	[57]
		Oncogene	RCC	Promote angiogenesis via modulating HIF-2α	[73]
	METTL14	Oncogene	Breast cancer	Promote angiogenesis via modulating VEGFA and RhoA and PI3K-Akt pathways	[27]
Erasers	FTO	Suppressor gene	ICC	FTO expression is inversely correlated with MVD.	[45]
	ALKBH5	Oncogene	Breast cancer	Promote angiogenesis via modulating VEGFA and RhoA and PI3K-Akt pathways	[27]
Readers	IGF2BP2	Oncogene	Lung cancer	Promote angiogenesis via modulating HNF4G/IGF2BP2/TK1 axis	[74]
	IGF2BP3	Oncogene	GC	Promote angiogenesis via enhancing HDGF mRNA stability	[58]
		Oncogene	CRC	Promote angiogenesis via modulating VEGF	[39]
		Oncogene	GBM	Promote angiogenesis via modulating PI3K/MAPK pathways	[75]
	YTHDF1	Oncogene	GC	Promote angiogenesis via modulating Wnt/β-catenin pathway	[32]
	YTHDF2	Suppressor gene	HCC	Suppress angiogenesis via downregulating IL11 and SERPINE2	[70]
	YTHDF3	Oncogene	Breast cancer	Promote angiogenesis via modulating VEGFA and EGFR	[71]

ISSN: 1476-4598