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Fig. 8 | Molecular Cancer

Fig. 8

From: Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation

Fig. 8

The signal pathway diagram of hsa_circ_0136666 promoting gastric cancer progression. Specifically, hsa_circ_0136666/miR-375/PRKDC upregulates DNA-PK protein expression, driving PD-L1 phosphorylation. The increased stability of PD-L1 results in abnormal aggregation on the surface of the cell membrane, thus leading to immune escape

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Molecular Cancer

ISSN: 1476-4598