Table 3 Representative clinical studies of dendritic cell vaccines for cancer immunotherapy

NCT00006434

Non-Hodgkin’s Lymphoma

Tumor lysate-pulsed DCs

3

Completed

NCT03905902

Ovarian cancer, fallopian tube cancer, peritoneal carcinoma

Autologous DCs (DCVAC/OvCa)

3

Withdrawn

NCT00779402

Prostate cancer

PAP-loaded DC vaccine (Sipuleucel-T)

3

Completed

NCT05100641

Glioblastoma

Therapeutic autologous DC vaccine (AV-GBM-1)

3

Not yet recruiting

NCT02503150

Colorectal cancer

Antigen-pulsed DCs

3

Unknown

NCT04277221

Glioblastoma

Autologous DC/tumor antigen

3

Unknown

NCT00005947

Prostate cancer

PAP-loaded DC vaccine (Sipuleucel-T)

3

Completed

NCT01759810

Glioblastoma

Proteome-based DC vaccine

3

Unknown

NCT01782287

Lung cancer brain metastases

Proteome-based DC vaccine

3

Unknown

NCT01983748

Uveal melanoma

Autologous DCs loaded with autologous tumor RNA

3

Active, not recruiting

NCT04348747

Brain metastasis from TNBC or HER2⁺ breast cancer

Anti-HER2/HER3 DC vaccine

2

Recruiting

NCT05127824

Kidney cancer

Autologous alpha-DC1/TBVA vaccine

2

Not yet recruiting

NCT04912765

Hepatocellular carcinoma or liver metastases From colorectal cancer

Neoantigen-loaded DC vaccine

2

Recruiting

NCT01876212

Melanoma

Type I-polarized autologous DC vaccine

2

Completed

NCT02285413

Melanoma

Mature DC loaded with mRNA encoding tumor-associated antigens gp100 and tyrosinase

2

Completed

NCT00266110

Breast cancer

Therapeutic autologous DCs

2

Completed

NCT02362464

Prostate cancer

Multi-epitope TARP peptide autologous DC vaccine

2

Completed

NCT01413295

Colorectal cancer

Autologous DCs loaded with autologous tumor antigens

2

Completed

NCT04487756

Lung cancer

Autologous DC vaccine

1/2

Recruiting

NCT02061332

Breast cancer

HER-2 pulsed DC vaccine

1/2

Completed

NCT00087984

Kidney cancer

RNA-loaded DC vaccine

1/2

Completed