Table 4 Macrophage-targeted immunotherapies for cancer patients

Inhibiting TAM recruitment and expansion

CCL2

Carlumab

NCT00992186

Prostate cancer

2

Carlumab

NCT01204996

Solid tumors

1

Carlumab

NCT00537368

Solid tumors

1

Trabectedin

NCT03085225

Soft-tissue sarcomas and ovarian carcinomas

1

CCR2

PF-04136309

NCT01413022

Pancreatic neoplasms

1

MLN1202

NCT01015560

Bone metastases

2

CSF-1

MCS110

NCT02435680

TNBC

2

NCT00757757

Prostate cancer, Bone Metastases

1/2

CSF-1R

IMC-CS4

NCT01346358

Solid tumors

1

AMG 820

NCT01444404

Solid tumors

1

Emactuzumab

NCT02323191

Solid tumors

1

ARRY-382

NCT02880371

Solid tumors

1/2

Pexidartinib

NCT02777710

Pancreatic and colorectal cancers

1

SNDX-6352

NCT03238027

Solid tumors

1

BLZ945

NCT02829723

Solid tumors

1/2

Cabiralizumab

NCT03158272

Malignancies

1

PLX7486

NCT01804530

Solid tumors

1

Regulating TAM activation

CD40

CP-870,893

NCT02225002

Advanced solid tumors

1

NCT01103635

Melanoma

1

NCT00607048

Neoplasms

1

NCT01456585

Adenocarcinoma pancreas

1

RO7009789

NCT02760797

Neoplasms

1

NCT02588443

Pancreatic cancer

1

NCT02665416

Solid tumors

1

TLR7/8

NKTR-262

NCT03435640

Solid tumors

1

STING

ADU-S100

NCT02675439

Advanced solid tumors and lymphomas

1

Targeting immune checkpoints

CD47

Hu5F9-G4

NCT03922477

Acute myeloid leukemia

1

TTI-621

NCT02663518

Hematologic malignancies and

solid tumors

1

CC-90002

NCT02641002

Acute myeloid leukemia

1

LILRB2

JTX 8064

NCT04669899

Solid tumors

1/2

IO-108

NCT05054348

Solid tumors

1

TAM metabolism regulators

Glucose metabolism

2-Deoxyglucose

NCT0063308

Advanced cancer and hormone refractory prostate cancer

1/2

Macrophage cell therapy

Her-2

CT-0508

NCT04660929

Her-2⁺ tumors

1

IFN-α2

TEMFERON

NCT03866109

Glioblastoma

1/2